Clinical Trials

Access to Novel Treatments and Promising New Therapies

Research at Cancer Partners

We Are Committed to Innovation

Cancer Partners of Nebraska offers unique access to clinical trials, thanks to our membership in two major National Cancer Institute (NCI) research networks: Alliance, as an MD Anderson Cancer Center affiliate, and ECOG-ACRIN Cancer Research Group.

  • Patient recruitment and enrollment in promising clinical trials is essential to the work that we do.
  • Cancer Partners is the first and only community oncology practice in Nebraska to become a member institution of the NCI clinical trials network.
  • The expanded clinical trials offered here bring academic-level treatment options to our local community.
  • We have access to over 300 new and innovative clinical trials for our patients.

Cancer Partners of Nebraska Human Research Protection Program

If you are not able to resolve your concerns with the study doctor or study staff, if you have a complaint, or if you have general questions about what it means to be in a research study, you can call the Cancer Partners of Nebraska Human Research Protection Program at (402) 420-7000, Ext. 202, or email HumanProtections@cancerpartners.com.

Clinical Trials

See What Clinical Trials Are Open Right Now

Most clinical trials at Cancer Partners are interventional studies, meaning patients are assigned to a treatment or other intervention and their outcomes are measured. See the full list below sorted by type of cancer. If you wish to discuss a specific trial, please discuss it with your oncologist or contact our Research Department at (402) 327-7363.

Breast Cancer

NRG-BR007/DEBRA - Stage I, s/p lumpectomy

A PHASE III CLINICAL TRIAL EVALUATING DEESCALATION OF BREAST RADIATION FOR CONSERVATIVE TREATMENT OF STAGE I, HORMONE SENSITIVE, HER2-NEGATIVE, ONCOTYPE RECURRENCE SCORE ≤ 18 BREAST CANCER

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NRG-BR008 - HER2+, Low Risk Breast Cancer

A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO*) *Her2 Radiation Optimization (HERO)

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OPERA-01 (OPEN) ER+/HER2-, advanced/Stage IV BC

A PHASE 3 RANDOMIZED, OPEN-LABEL STUDY OF OP-1250 MONOTHERAPY VS STANDARD OF CARE FOR THE TREATMENT OF ER+, HER2– ADVANCED OR METASTATIC BREAST CANCER FOLLOWING ENDOCRINE AND CDK 4/6 INHIBITOR THERAPY (OPERA-01)

Central Nervous System Tumors (Brain and Spinal Cord) Cancer

Hematologic Cancer

CONNECT MDS/AML Myeloid Disorders

The Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) Disease Registry

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S1918 (DLBCL age >75) Diffuse Large B Cell Lymphoma

A Phase II/III Randomized Study of R-MiniCHOP with or Without CC-486 (Oral Azacitidine) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas with MYC AND BCL2 and/or BCL6 Rearrangements

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S1925 Asymptomatic High-Risk CLL/SLL

Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed therapy with Venetoclax and Obinutzumab in Newly Diagnosed Asymptomatic High-Risk Patient with DLL/CLL: EVOLVE CLL/SLL Study.

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EAA181 (EQUATE) - MM, newly diagnosed, no transplant planned

A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma not Intended for Early Autologous Transplantation

Registry, RRMM CC-5013-MM-036 (Connect MM)

The Multiple Myeloma Disease Registry

S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration (DRAMMATIC)

Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as post-autologous stem cell transplant maintenance therapy in patients with MM using minimal residual disease to direct therapy duration (DRAMMATIC STUDY).

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Gastrointestinal Cancer

NRG-GI008 Stage IIb-III colon, resected

COLON ADJUVANT CHEMOTHERAPY BASED ON EVALUATION OF RESIDUAL DISEASE (CIRCULATE-NORTH AMERICA)

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Thoracic Cancer

Stage IV EGFR Mutated NSCLC 1st line treatment - EA5182

Randomized Phase III Study of Combination AZD9291 (Osimertinib) and Bevacizumab Versus AZD9291 (Osimertinib) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)

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ES-SCLC, 1st line - ASTRIDE

A Randomized, Open-label Study of HLX10 plus Chemotherapy (Carboplatin-Etoposide) in comparison with Atezolizumab plus Chemotherapy in Previously Untreated US Patients with Extensive Stage Small Cell Lung Cancer (ES-SCLC)

A151216 - Resected Non-Small Cell Lung Cancer

Stage II-III Resected NSCLC – Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

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Stage II-III Resected NSCLC - A081801

Integration of Immunotherapy into Adjuvant Therapy for Resected NSCLC: ALCHEMIST CHEMO-IO (ACCIO)

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ES/LS-SCLC S1827

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-NORTH AMERICA)

A081801 - Stage II-III (Resected Non-Small Cell Lung Cancer)

Integration of Immunotherapy into Adjuvant Therapy for Resected NSCLC: ALCHEMIST CHEMO-IO (ACCIO)

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LS-SCLC HLX10-020-SCLC302

A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of HLX10 (Recombinant Humanized Anti-PD-1 Monoclonal Antibody Injection) or Placebo in Combination with Chemotherapy (Carboplatin/Cisplatin-Etoposide) and Concurrent Radiotherapy in Patients with Limited-Stage Small Cell Lung Cancer (LS-SCLC)

Genitourinary Cancer

NRG-GU008 (INNOVATE) - Prostate Cancer, Treatment after Prostatectomy

Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer after Radical Prostatectomy

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Gynecological

Stage II-IV, low grade serous NRG-GY019

A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum

Neuroendocrine

SSTR+ Pancreatic NET A022001

Phase II Randomized, Prospective Trial of Lutetium Lu 177 Dotatate PRRT Versus Capecitabine and Temozolomide in Well-Differentiated Pancreatic Neuroendocrine Tumors

Solid Tumor

Cutaneous

Mutation Targeted Therapies

ULI-EAP-100 (XCURES)

MAPK Pathway Altered Malignancies – Expanded Ulixertinib (BVD-523) access in Patients with Advanced MAPK Pathway-Altered Malignancies.

Biomarker

S2013 (ON HOLD)

Starting Immunotherapy- Immune Checkpoint Inhibitor Toxicity (I-CHECKIT): A Prospective Observational Study

MT Group (MTG-022)

The list of available biomarker studies is always changing. Please contact Cancer Partners Research Department for the most current list.

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