Clinical Trials

Access to Novel Treatments and Promising New Therapies

Research at Cancer Partners

We Are Committed to Innovation

Cancer Partners of Nebraska can now offer even more access to clinical trials, thanks to our membership in two major National Cancer Institute (NCI) research networks: Alliance as an affiliate of MD Anderson Cancer Center and ECOG-ACRIN Cancer Research Group.

  • Patient recruitment and enrollment in promising clinical trials is essential to the work that we do.
  • Cancer Partners is the first and only community oncology practice in Nebraska to become a member institution of the NCI clinical trials network.
  • The expanded clinical trials offered here bring academic-level treatment options to our local community.
  • We have access to over 300 new and innovative clinical trials for our patients.

Cancer Partners of Nebraska Human Research Protection Program

If you are not able to resolve your concerns with the study doctor or study staff, if you have a complaint, or if you have general questions about what it means to be in a research study, you can call the Cancer Partners of Nebraska Human Research Protection Program at (402) 420-7000, Ext. 202, or email

Clinical Trials

See What Clinical Trials Are Open Right Now

Most clinical trials at Cancer Partners are interventional studies, meaning patients are assigned to a treatment or other intervention and their outcomes are measured. See the full list below sorted by type of cancer. If you wish to discuss a specific trial, please discuss it with your oncologist or contact our Research Department at (402) 327-7363.

Breast Cancer

NRG-BR004 – HER-2 Positive Metastatic Breast Cancer

A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer

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EA1181 – Her-2 positive Stage II-IIIa Breast Cancer

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

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Central Nervous System Tumors (Brain and Spinal Cord) Cancer

A071702 - WHO Grade IV GBM (Glioblastoma)

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioblastoma With Elevated Mutational Burden

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NRG-BN007 (Glioblastoma)

Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

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Hematologic Cancer

CONNECT MDS/AML Myeloid Disorders

The Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) Disease Registry

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SUMMIT (Mantle Cell Lymphoma)

Treatment Patterns, Outcomes, and Patient-Reported Health-Related Quality of Life:  A Prospective Disease Registry of Patients with Mantle Cell Lymphoma Treated with Novel Agents

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INNOCARE ICP-CL-00107 (B-Cell Malignancies)

A Phase I/II, Multicenter, Open-label, Study of a Novel Bruton’s Tyrosine Kinase Inhibitor, Orelabrutinib. R/R MCL, MZL, FL or Dbl mutated DLBCL, and R/R or Treatment Naïve CLL/SLL

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S1918 (DLBCL age >75) Diffuse Large B Cell Lymphoma

A Phase II/III Randomized Study of R-MiniCHOP with or Without CC-486 (Oral Azacitidine) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas with MYC AND BCL2 and/or BCL6 Rearrangements

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Gastrointestinal Cancer

A221805 – Stage II-III Colon Cancer Receiving Oxaliplatin (Early Stage Colon Cancer)

Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study

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EA2186 GIANT - Metastatic Pancreatic

1ST line Metastatic Pancreatic – A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients with Treatment Naïve Metastatic Pancreatic Cancer (GIANT)

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2nd line mCRC, KRAS G12C mutated – A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy

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Advanced Colorectal Cancer with KRAS G12C Mutation

Phase 3 Study of MRTX849 with Cetuximab vs Chemotherapy. Mirati 849-010. Advanced or Stage IV CRC with KRAS G12C Mutation

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MK7339-003 (LYNK-003) – (Metastatic Colorectal Cancer) 1ST line FOLFOX + Avastin

A Phase 3 Randomized, Open-label Study to Evaluate the Efficacy and Safety of Olaparib Alone or in Combination With Bevacizumab Compared to Bevacizumab With 5-FU in Participants with Unresectable or Metastatic Colorectal Cancer who Have not Progressed Following First-line Induction of FOLFOX With Bevacizumab (LYNK-003)

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Thoracic Cancer

D910LC00001 (MeRmaiD-1) Operable Non-Small Cell Lung Cancer

Stage II-III Resected NSCLC – A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled Study to Determine the Efficacy of Adjuvant Durvalumab in Combination with Platinum-based Chemotherapy in Completely Resected Stage II-III NSCLC

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LS-SCLC NRG-LU005 - Limited Stage Small Cell Lung Cancer

Chemoradiation With or Without Atezolizumab in Treating Patients With Limited Stage Small Cell Lung Cancer

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A151216 - Resected Non-Small Cell Lung Cancer

ON HOLD – Stage II-III Resected NSCLC – Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

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EA5182 - Stage IV EGFR Mutated NSCLC 1st line treatment (Metastatic Non-Small Cell lung cancer, EGRF Mutated)

Randomized Phase III Study of Combination AZD9291 (Osimertinib) and Bevacizumab Versus AZD9291 (Osimertinib) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)

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GX41563 - mNSCLC or ES-SCLC (Extensive Stage Small Cell Lung Cancer)

A Multicenter, Low-Interventional Study to Evaluate the Feasibility of a Prospective Clinicogenomic Program

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D910MC00001 (MeRmaiD-2) - Stage II-III Resected NSCLC (Operable Non-Small Cell Lung Cancer)

A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled Study of Durvalumab for the Treatment of Stage II-III NSCLC Patients With Minimal Residual Disease Following Surgery and Curative Intent Therapy

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A081801 - Stage II-III (Resected Non-Small Cell Lung Cancer)

ON HOLD – Integration of Immunotherapy into Adjuvant Therapy for Resected NSCLC: ALCHEMIST CHEMO-IO (ACCIO)

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E4512 - Stage II-III ALK + Resected Non-Small Cell Lung Cancer

A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

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EA5181 - Unresectable Stage III Non-Small Cell Lung Cancer

Randomized Phase III Trial of MEDI4736 (durvalumab) as Concurrent and Consolidative Therapy of Consolidative Therapy Alone for Unresectable Stage 3 NSCLC

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Genitourinary Cancer

A031704 (PDIGREE) - Treatment Naïve Metastatic Renal Cell Carcinoma

PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab Vs. VEGF TKI Cabozantinib with Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE]

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NRG-GU008 (INNOVATE) - Prostate Cancer, Treatment after Prostatectomy (TEMPORARILY CLOSED)

Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer after Radical Prostatectomy

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MK6482-011 - Progressive Metastatic Renal Cell Carcinoma

Phase 3 Study of MK-6482 in Combination With Lenvatinib Versus Cabozantinib for Second-line Treatment of mRCC

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Solid Tumor

MK7339-002 (LYNK-002) Previously Treated, HRR/HRD + (Solid Tumors with Targetable Genomic Alterations)

A Phase 2 Study of Olaparib Monotherapy in Participants with Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer

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ML42439 (MyTactic) - Solid Tumors with Targetable Genomic Alterations

An Open-Label Phase II Study Evaluating Targeted Therapies in Patients Who Have Advanced Solid Tumors with Genomic Alterations or Protein Expression Patterns Predictive of Response

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CASE - Cutaneous Squamous Cell Carcinoma

Cemiplimab Survivorship Epidemiology Study

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S2000 - Metastatic Melanoma

A Randomized Phase II Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma with Brain Metastases

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A221602 - Prevention of Chemotherapy Induced Nausea and Vomiting

Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

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Caris Biorepository (Matched Tumor)

Solid Tumor Matched Tissue and Blood Collection

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MT Group (MTG-022)

The list of available biomarker studies is always changing. Please contact Cancer Partners Research Department for the most current list.

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